| Pathologic response to preoperative therapy: does it mean what we think it means? | |
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MedLine Citation:
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PMID: 19326170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumors treated with preoperative chemotherapy or radiation often demonstrate evidence of response in the resection specimen. Pathologic response is often interpreted as a surrogate for recurrence or survival outcomes. With a valid surrogate for long-term outcomes, investigators can explore treatment strategies with immediate endpoints. The financial and time costs of trials measuring recurrence and survival may be lessened by using short-term pathologic outcomes as an endpoint. This review is intended to examine the current status of pathologic response as a surrogate for tumor behavior. We address questions regarding the definitions of pathologic response, as well as the current literature regarding the meaning of pathologic response for some common tumor types. We explore some of the potential confounding effects that may explain the frequent discordance between tumor response and patient outcomes. In addition, we address some alternative strategies to gauge the response of a tumor to preoperative therapy. |
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Authors:
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John C Mansour; Roderich E Schwarz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-03-27 |
Journal Detail:
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Title: Annals of surgical oncology Volume: 16 ISSN: 1534-4681 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1465-79 Citation Subset: IM |
Affiliation:
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Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center at Dallas, USA. john.mansour@utsouthwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage Chemotherapy, Adjuvant Combined Modality Therapy Humans Neoadjuvant Therapy Neoplasms / mortality, pathology*, physiopathology, therapy* Neoplastic Processes Radiotherapy, Adjuvant Remission Induction Survival Analysis |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR024982/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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