Document Detail

Pathologic lesions in neurodegenerative diseases.
MedLine Citation:
PMID:  22482446     Owner:  NLM     Status:  In-Data-Review    
This chapter will discuss two of the most widely used approaches to assessing brain structure: neuroimaging and neuropathology. Whereas neuropathologic approaches to studying the central nervous system have been utilized for many decades and have provided insights into morphologic correlates of dementia for over 100 years, accurate structural imaging techniques "blossomed" with the development and refinement of computerized tomographic scanning and magnetic resonance imaging (MRI), beginning in the late 1970s. As Alzheimer disease progresses over time, there is progressive atrophy of the hippocampus and neocortex-this can be quantified and regional accentuation of the atrophy can be evaluated using quantitative MRI scanning. Furthermore, ligands for amyloid proteins have recently been developed-these can be used in positron emission tomography studies to localize amyloid proteins, and (in theory) study the dynamics of their deposition (and clearance) within the brain over time. Neuropathologic studies of the brain, using highly specific antibodies, can demonstrate synapse loss and the deposition of proteins important in AD progression-specifically ABeta and phosphor-tau. Finally, neuropathologic assessment of (autopsy) brain specimens can provide important correlation with sophisticated neuroimaging techniques.
Paul M Thompson; Harry V Vinters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in molecular biology and translational science     Volume:  107     ISSN:  1878-0814     ISO Abbreviation:  Prog Mol Biol Transl Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101498165     Medline TA:  Prog Mol Biol Transl Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Laboratory of Neuro Imaging, David Geffen School of Medicine at UCLA & UCLA Medical Center, Los Angeles, California, USA.
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