Document Detail


Pathologic human vitreous promotes contraction by fibroblasts. Implications for proliferative vitreoretinopathy.
MedLine Citation:
PMID:  7487624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To establish and quantify the presence of contraction-stimulating activity in pathologic vitreous and correlate this activity with clinical presentation and outcome, especially with proliferative vitreoretinopathy. METHODS: Contraction-stimulating activity of vitreous collected during surgery was quantified with a tissue culture assay using fibroblasts as target cells. The activity of each sample was correlated with patient history, clinical presentation, risk factors, proliferative disease, and postoperative proliferation. RESULTS: Pathologic vitreous contained measurable quantities of contraction-stimulating activity and stimulated contraction in vitro, with elevated activities in samples from patients with proliferative vitreoretinopathy, epimacular proliferation, retinal detachment, retinal defects, pigmented cells in the vitreous, hemorrhage, or uveitis. Patients with postoperative proliferation had significantly elevated mean activities. CONCLUSIONS: Levels of contraction-stimulating activity in pathologic vitreous correlate with some risk factors for the development of proliferative vitreoretinopathy and may ultimately be useful in the assessment of disease severity and the prediction of postoperative proliferation.
Authors:
C Hardwick; R Morris; D Witherspoon; M White; R Feist; R McFarland; C Guidry
Related Documents :
19116914 - Requirement of transforming growth factor beta-activated kinase 1 for transforming grow...
8016894 - Tyrosine kinase pathways and the regulation of smooth muscle contractility.
1855124 - A selective effect of protein kinase c activators on noradrenaline release compared wit...
11136944 - Ethanol-induced contractions in cerebral arteries: role of tyrosine and mitogen-activat...
9521814 - Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nu...
25143274 - Regulation of pollen tube growth by reversible protein phosphorylation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  113     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1545-53     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, University of Alabama at Birmingham, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Factors / physiology*
Cell Division
Cells, Cultured
Child
Collagen / physiology
Female
Fibroblasts / drug effects,  physiology*
Humans
Male
Middle Aged
Retinal Diseases / surgery
Skin / cytology
Transforming Growth Factor beta / pharmacology
Vitrectomy
Vitreoretinopathy, Proliferative / diagnosis*
Vitreous Body* / chemistry,  pathology
Grant Support
ID/Acronym/Agency:
EYO7033/EY/NEI NIH HHS; EYO9536/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Factors; 0/Transforming Growth Factor beta; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypoxic regulation of vascular endothelial growth factor in retinal cells.
Next Document:  Histopathologic study of autosomal dominant vitreoretinochoroidopathy in a 26-year-old woman.