Document Detail


Pathologic human vitreous promotes contraction by fibroblasts. Implications for proliferative vitreoretinopathy.
MedLine Citation:
PMID:  7487624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To establish and quantify the presence of contraction-stimulating activity in pathologic vitreous and correlate this activity with clinical presentation and outcome, especially with proliferative vitreoretinopathy. METHODS: Contraction-stimulating activity of vitreous collected during surgery was quantified with a tissue culture assay using fibroblasts as target cells. The activity of each sample was correlated with patient history, clinical presentation, risk factors, proliferative disease, and postoperative proliferation. RESULTS: Pathologic vitreous contained measurable quantities of contraction-stimulating activity and stimulated contraction in vitro, with elevated activities in samples from patients with proliferative vitreoretinopathy, epimacular proliferation, retinal detachment, retinal defects, pigmented cells in the vitreous, hemorrhage, or uveitis. Patients with postoperative proliferation had significantly elevated mean activities. CONCLUSIONS: Levels of contraction-stimulating activity in pathologic vitreous correlate with some risk factors for the development of proliferative vitreoretinopathy and may ultimately be useful in the assessment of disease severity and the prediction of postoperative proliferation.
Authors:
C Hardwick; R Morris; D Witherspoon; M White; R Feist; R McFarland; C Guidry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  113     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1545-53     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, University of Alabama at Birmingham, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Factors / physiology*
Cell Division
Cells, Cultured
Child
Collagen / physiology
Female
Fibroblasts / drug effects,  physiology*
Humans
Male
Middle Aged
Retinal Diseases / surgery
Skin / cytology
Transforming Growth Factor beta / pharmacology
Vitrectomy
Vitreoretinopathy, Proliferative / diagnosis*
Vitreous Body* / chemistry,  pathology
Grant Support
ID/Acronym/Agency:
EYO7033/EY/NEI NIH HHS; EYO9536/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Factors; 0/Transforming Growth Factor beta; 9007-34-5/Collagen

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