| Pathologic human vitreous promotes contraction by fibroblasts. Implications for proliferative vitreoretinopathy. | |
| | |
MedLine Citation:
|
PMID: 7487624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To establish and quantify the presence of contraction-stimulating activity in pathologic vitreous and correlate this activity with clinical presentation and outcome, especially with proliferative vitreoretinopathy. METHODS: Contraction-stimulating activity of vitreous collected during surgery was quantified with a tissue culture assay using fibroblasts as target cells. The activity of each sample was correlated with patient history, clinical presentation, risk factors, proliferative disease, and postoperative proliferation. RESULTS: Pathologic vitreous contained measurable quantities of contraction-stimulating activity and stimulated contraction in vitro, with elevated activities in samples from patients with proliferative vitreoretinopathy, epimacular proliferation, retinal detachment, retinal defects, pigmented cells in the vitreous, hemorrhage, or uveitis. Patients with postoperative proliferation had significantly elevated mean activities. CONCLUSIONS: Levels of contraction-stimulating activity in pathologic vitreous correlate with some risk factors for the development of proliferative vitreoretinopathy and may ultimately be useful in the assessment of disease severity and the prediction of postoperative proliferation. |
| | |
Authors:
|
C Hardwick; R Morris; D Witherspoon; M White; R Feist; R McFarland; C Guidry |
Related Documents
:
|
19116914 - Requirement of transforming growth factor beta-activated kinase 1 for transforming grow... 8016894 - Tyrosine kinase pathways and the regulation of smooth muscle contractility. 1855124 - A selective effect of protein kinase c activators on noradrenaline release compared wit... 11136944 - Ethanol-induced contractions in cerebral arteries: role of tyrosine and mitogen-activat... 9521814 - Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nu... 19164584 - Learning-related postburst afterhyperpolarization reduction in ca1 pyramidal neurons is... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Archives of ophthalmology Volume: 113 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1995 Dec |
Date Detail:
|
Created Date: 1995-12-21 Completed Date: 1995-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1545-53 Citation Subset: AIM; IM |
Affiliation:
|
Department of Ophthalmology, University of Alabama at Birmingham, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Biological Factors / physiology* Cell Division Cells, Cultured Child Collagen / physiology Female Fibroblasts / drug effects, physiology* Humans Male Middle Aged Retinal Diseases / surgery Skin / cytology Transforming Growth Factor beta / pharmacology Vitrectomy Vitreoretinopathy, Proliferative / diagnosis* Vitreous Body* / chemistry, pathology |
| Grant Support | |
ID/Acronym/Agency:
|
EYO7033/EY/NEI NIH HHS; EYO9536/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Factors; 0/Transforming Growth Factor beta; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypoxic regulation of vascular endothelial growth factor in retinal cells.
Next Document: Histopathologic study of autosomal dominant vitreoretinochoroidopathy in a 26-year-old woman.