| Pathologic findings in a steroid-responsive optic nerve infarct in giant-cell arteritis. | |
| | |
MedLine Citation:
|
PMID: 10408556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the pathophysiologic mechanism of optic nerve infarction in giant-cell arteritis (GCA). BACKGROUND: Previous pathologic reports of optic nerve infarction in GCA involved patients who were blind at the time of death. The optic nerve infarcts were primarily retrolaminar in localization. Simultaneous short ciliary and ophthalmic artery vasculitis was found in all patients. METHODS: Clinical neurologic and ophthalmologic examination, temporal artery biopsy, and neuroimaging tests were performed in a patient with an anterior ischemic optic neuropathy secondary to GCA. Pathologic examination of the viscera, eye, and brain were performed at autopsy 1 month later. RESULTS: A prelaminar/retrolaminar infarct was found in this patient. Subsiding vasculitis was limited to the short ciliary arteries, sparing the central retinal, pial, and ophthalmic arteries. CONCLUSIONS: The authors believe that the visual improvement observed in this patient was the result of preserved, anterior optic nerve collateral circulation, as well as the neuroprotective and anti-inflammatory effect of the corticosteroids. |
| | |
Authors:
|
J C Kattah; L Mejico; G A Chrousos; L E Zimmerman; H J Manz |
Related Documents
:
|
3941966 - Basilar artery occlusion after superficial temporal artery-superior cerebellar artery a... 6842706 - Concomitant carotid, mesenteric and renal artery stenosis due to primary intimal fibrop... 7171296 - Morphological and clinical analysis of extra-intracranial bypass. 2. histological and h... 8798016 - Initial isolated takayasu's arteritis of the right pulmonary artery: mr appearance. 15363996 - Differences in the vascular selectivity and tolerance between the no donor/beta-blocker... 16452056 - Evaluation of patients after treatment of arterial priapism with selective micro-emboli... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Neurology Volume: 53 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1999 Jul |
Date Detail:
|
Created Date: 1999-08-09 Completed Date: 1999-08-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 177-80 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, University of Illinois College of Medicine at Peoria, 61656-1649, USA. kattahj@uic.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Anti-Inflammatory Agents / therapeutic use* Autopsy Female Giant Cell Arteritis / complications, pathology*, physiopathology Humans Infarction / complications, drug therapy*, pathology*, physiopathology Methylprednisolone / therapeutic use* Optic Nerve / pathology*, physiopathology Temporal Arteries / pathology Vasculitis / complications, pathology Visual Acuity |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diffusion mapping applied to mesial temporal lobe epilepsy: preliminary observations.
Next Document: An inherited prion disease with a PrP P105L mutation: clinicopathologic and PrP heterogeneity.