| Pathologic features of sharp curettings in complete hydatidiform mole. Predictors of persistent gestational trophoblastic disease. | |
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MedLine Citation:
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PMID: 1848894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The medical records and pathologic specimens were reviewed from 33 patients with complete molar pregnancy at Brigham and Women's Hospital between 1980 and 1989. Two pathologists (D.R.G. and R.W.R.) reviewed all slides from the original sharp curettage to identify pathologic features that may be associated with persistent gestational trophoblastic tumor (GTT). The pathologic features evaluated were implantation site, presence of myometrium, presence of villi, presence and degree of atypia in cytotrophoblast, syncytiotrophoblast and intermediate trophoblast, presence of fibrinoid, presence of implantation site inflammatory cells, volume of tissue and area of trophoblastic tissue. Only one pathologic feature, fibrinoid deposits, identified in sharp curettings was associated with the development of persistent GTT. While 12 (48%) of 25 patients who attained remission without chemotherapy had fibrinoid deposits, only 1 (12.5%) of 8 patients who developed persistent GTT had them (P less than .10). |
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Authors:
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L W Rice; D R Genest; R S Berkowitz; D P Goldstein; M R Bernstein; R W Redline |
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18224314 - The frontosphenoidal suture: fetal development and phenotype of its synostosis. 20103454 - Early molar pregnancy: experience in a large abortion service. 7422894 - Induction of labour with sulprostone after foetal death and in hydatidiform mole. 20046254 - Molar pregnancy in the emergency department. 1445124 - Clinical versus ultrasound estimation of fetal weight. 23554274 - Uterine vasculature remodelling in human pregnancy involves functional macro-chimerism ... |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 36 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-04-26 Completed Date: 1991-04-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 17-20 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Harvard Medical School, Boston, MA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Boston / epidemiology Female Humans Hydatidiform Mole / classification, complications, pathology* Predictive Value of Tests Pregnancy Trophoblastic Neoplasms / epidemiology*, etiology Uterine Neoplasms / classification, complications, pathology* Vacuum Curettage / standards* |
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