Document Detail


Pathologic features of polycystic thyroid disease: comparison with benign nodular goiter.
MedLine Citation:
PMID:  21737959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polycystic thyroid disease (PCTD) is characterized by multiple thyroid cysts detected by ultrasonography, the absence of thyroid autoantibodies, and susceptibility to the development of hypothyroidism due to a high iodine intake. It is necessary to obtain histopathological information on PCTD in order to clarify the cause of hypothyroidism. We retrospectively reviewed three patients with PCTD and small papillary thyroid cancer who underwent thyroidectomy. We observed the thyroid tissues pathologically in areas with and without multiple cysts, and compared them with those of multinodular goiter with cysts. In the patients with PCTD, there were multiple enlarged follicles that resembled enlarged normal follicles and differed from those found in multinodular goiter in terms of their shape. Huge follicles corresponded to the cysts that were detected by ultrasonography. Each follicle contained colloid. Follicular cells in enlarged follicles comprised low cuboidal epithelium that appeared normal. These findings were common in the 3 patients with PCTD. In Conclusion the PCTD patients had multiple enlarged follicles that seemed to decrease the total number of follicular cells, and may be a cause of hypothyroidism. We believe that PCTD is a new entity of thyroid disease based on the pathological findings.
Authors:
Sumihisa Kubota; Mitsuyoshi Hirokawa; Yuki Takamura; Yasuhiro Ito; Hidekazu Tamai; Takumi Kudo; Eijun Nishihara; Mitsuru Ito; Nobuyuki Amino; Akira Miyauchi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-07-07
Journal Detail:
Title:  Endocrine journal     Volume:  58     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-30     Completed Date:  2012-04-02     Revised Date:  2012-05-03    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  783-8     Citation Subset:  IM    
Affiliation:
Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-ku, Kobe, Japan. kubota@kuma-h.or.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Papillary / blood,  pathology*,  ultrasonography
Cysts / blood,  pathology*,  ultrasonography
Female
Goiter, Nodular / blood,  pathology*,  ultrasonography
Histocytochemistry
Humans
Male
Middle Aged
Retrospective Studies
Thyroid Neoplasms / blood,  pathology*,  ultrasonography
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Chemical
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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