Document Detail

Pathologic dependence of oxygen consumption on oxygen delivery in acute respiratory failure secondary to AIDS-related Pneumocystis carinii pneumonia.
MedLine Citation:
PMID:  2245689     Owner:  NLM     Status:  MEDLINE    
Oxygen consumption is pathologically dependent on oxygen delivery in ARDS and sepsis. We asked whether oxygen consumption is dependent on oxygen delivery in severe acute respiratory failure secondary to AIDS-related PCP. In five patients who had AIDS-related PCP, diffuse bilateral pulmonary infiltrates, no evidence of bacterial infection, and acute respiratory failure requiring mechanical ventilation with arterial oxygen tensions less than 75 mm Hg while breathing at least 50 percent oxygen, and PEEP greater than 10 cm H2O, we determined oxygen delivery and consumption by calculation from thermodilution cardiac output and arterial and mixed venous oxygen contents. Oxygen delivery was increased using transfusion of two units of packed red blood cells over one hour. Oxygen delivery increased 22 percent (638 +/- 204 to 778 +/- 201 ml/min.m2, p less than or equal to 0.006). Oxygen consumption increased 11 percent (134 +/- 34 to 149 +/- 29 ml/min.m2, p less than or equal to 0.02). The oxygen extraction ratio did not change. We conclude that similar to ARDS and sepsis, oxygen consumption may be pathologically dependent on oxygen delivery in patients who have severe acute respiratory failure secondary to AIDS-related PCP.
J J Ronco; J S Montaner; J C Fenwick; J Ruedy; J A Russell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  98     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-09     Completed Date:  1991-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1463-6     Citation Subset:  AIM; IM; X    
Department of Medicine, St. Pauls Hospital University of British Columbia, Vancouver, Canada.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*
Blood Transfusion
Cardiac Output
Oxygen / blood*
Oxygen Consumption*
Pneumonia, Pneumocystis / complications*
Positive-Pressure Respiration
Respiration, Artificial
Respiratory Insufficiency / blood,  etiology,  physiopathology*,  therapy
Reg. No./Substance:

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