Document Detail


Pathologic characteristics of the torn human meniscus.
MedLine Citation:
PMID:  17092929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acellular meniscus tissue is at a high risk for degeneration and retear. Information that would help surgeons predict, preoperatively, or intraoperatively which torn menisci had few viable cells could be useful in deciding which patients might be at increased risk for retear and failure of surgical repair. HYPOTHESIS: Patient age, length of time since injury, and tear type are predictors of the cellularity of meniscus tissue. STUDY DESIGN: Descriptive laboratory study. METHODS: Gross and histologic evaluation of torn meniscus tissue from 44 patients and 10 control menisci was performed. RESULTS: The patient factors of age, time since injury, and tear type all had significant effects on the pathologic characteristics of the torn meniscus. Patients older than 40 years had lower cellularity in the torn menisci than did patients younger than 40 years (P < .01). As time since injury increased, so did the rates of DNA fragmentation in the midsubstance of the meniscus and rates of Outerbridge II changes in the adjacent cartilage. Worse meniscal histologic scores were found in menisci with degenerative and radial tear types. CONCLUSION: Patient age had a significant effect on the cellularity of the torn meniscus, with patients older than 40 years having significantly fewer meniscus cells than did those younger than 40 years. Further studies are needed to define the relative importance of the individual histologic findings in the clinical setting of meniscus tear and repair. CLINICAL RELEVANCE: In light of their decreased cellularity, menisci from patients older than 40 years may be more vulnerable to degeneration and retear after repair than are menisci of younger patients.
Authors:
Mena Mesiha; David Zurakowski; Jamil Soriano; Jason H Nielson; Bertram Zarins; Martha M Murray
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-11-07
Journal Detail:
Title:  The American journal of sports medicine     Volume:  35     ISSN:  0363-5465     ISO Abbreviation:  Am J Sports Med     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-03     Completed Date:  2007-03-15     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7609541     Medline TA:  Am J Sports Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Analysis of Variance
Case-Control Studies
Cell Proliferation
DNA Fragmentation
Female
Humans
Immunoenzyme Techniques
In Situ Nick-End Labeling
Logistic Models
Male
Menisci, Tibial / cytology,  injuries,  pathology*
Middle Aged
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
K02AR049346/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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