Document Detail

Pathologic bone alterations in celiac disease: Etiology, epidemiology, and treatment.
MedLine Citation:
PMID:  24290593     Owner:  NLM     Status:  In-Data-Review    
Low bone mineral density (BMD), osteopenia, and osteoporosis are frequent complications of celiac disease (CD). The etiology of pathologic bone alterations in CD is multifactorial; however, two main mechanisms are involved: intestinal malabsorption and chronic inflammation. A strict gluten-free diet (GFD) is thought to be the only effective treatment for CD; but treating bone complications related to CD remains complex. The objective of this review is to elucidate the bones problems related to CD and to increase awareness of osteoporosis development, considered as a sign of atypical CD presentation. Currently, a question of whether GFD alone is an effective treatment to correct the bone alterations in patients with CD is under debate. This review presents factors contributing to pathologic bone derangement, recent research on the epidemiology of low BMD, osteoporosis, and fractures, and the treatment of bone problems in patients with CD. The roles of calcium and transport mechanisms are additionally presented.
Urszula Krupa-Kozak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  30     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Department of Chemistry and Biodynamics of Food, Olsztyn, Poland. Electronic address:
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