Document Detail

Pathologic basis of improving the screening utility of 2-dimensional placental morphology ultrasound.
MedLine Citation:
PMID:  22841938     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To determine the utility of measuring maximum placental length in the second trimester to predict a small for gestational age placenta by weight at delivery in clinically high-risk women. STUDY DESIGN: Placental dimensions determined by 2-dimensional (2-D) real-time ultrasound at 19-23 weeks' gestation were compared to post-natal placental weights and pathology in 95 high-risk patients with singleton pregnancies. RESULTS: Maximum placental length <10.0 cm performed poorly (false positive rate 25.5%) for the detection of a small placenta by weight at delivery. Placental pathology examination revealed eccentric cord insertion to be an important explanation for poor screening test result, since this finding was significantly more common in the false negative group (length ≥10.0 cm, weight <10th percentile) compared with the true negative group (length ≥10.0 cm, weight ≥10th percentile) (15/28 vs. 9/38, Fisher's exact test, p = 0.005). CONCLUSIONS: Prediction of reduced placental weight by 2-D ultrasound determination of maximum placental length in clinically high-risk pregnancies confounded by the phenomenon of asymmetric chorion regression. Refinement of 2-D ultrasound methods to include orthogonal plane measurements, or replacement by 3-D techniques is predicted to significantly improve the effectiveness of diagnosing small placentas in-utero.
D Costantini; M Walker; N Milligan; S Keating; J Kingdom
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Canada; Department of Community and Family Medicine, University of Toronto, Canada.
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