Document Detail

Pathologic alterations of the heart and the kidney in patients with ankylosing spondylitis.
MedLine Citation:
PMID:  18024267     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The occurrence of a variety of pathological lesions of the heart and kidneys have been described in patients with ankylosing spondylitis (AS). The frequency of these alterations and whether they are specific for AS has been discussed controversially. - METHODS: Outpatients with AS were studied to determine the frequency of cardiac and renal alterations and to assess the associated clinical and demographic factors. - RESULTS: A total of 77 patients with AS participated in the study (male 84.4%, mean age 48.3 +/- 1.5 years, mean duration of disease 15.4 +/- 1.2 years). Hypertension was present in 36.4% and diabetes mellitus in 13.0%. Impaired renal function (defined by a decrease in GFR) combined with markers of kidney damage suspective for chronic kidney disease were present in 3 patients (3.9%). Pathologic alterations of the heart were found in 25 patients (37.3%). Echocardiographic abnormalities were present in 20 patients (e.g. aortic and mitral insufficiency). Electrocardiographic abnormalities were present in 12 patients (e.g. atrioventricular, left and right branch block). Patients with cardiac abnormalities were older (54.2 +/- 2.9 vs. 44.9 +/- 1.7 years) and had a longer duration of disease (20.6 +/- 2.1 vs. 13.9 +/- 1.6 years) as compared to non-affected patients. - CONCLUSION: In our study, cardiac abnormalities were frequently seen in patients with AS, while renal disease was more rare and might be due to diseases not related to AS in most of patients. In contrast to cardiac involvement, it therefore appears questionable, that chronic kidney disease is part of the extraskeletal manifestations, or at least that AS has a high impact on renal integrity.
U Lange; G Stapfer; T Ditting; H Geiger; J Teichmann; U Müller-Ladner; O Jung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of medical research     Volume:  12     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  573-81     Citation Subset:  IM    
Kerckhoff Clinic and Foundation - Department of Rheumatology, University of Giessen, Bad Nauheim, Germany.
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MeSH Terms
Heart Diseases / complications,  diagnosis*,  pathology
Kidney / pathology
Kidney Diseases / complications,  diagnosis*,  pathology
Middle Aged
Myocardium / pathology
Spondylitis, Ankylosing / complications*

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