| Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. | |
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MedLine Citation:
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PMID: 20008645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To estimate the rate of pathologic complete response (pCR) to neoadjuvant chemotherapy in BRCA1 mutation carriers according to chemotherapy regimen. PATIENTS AND METHODS: From a registry of 6,903 patients, we identified 102 women who carried a BRCA1 founder mutation and who had been treated for breast cancer with neoadjuvant chemotherapy. Pathologic complete response was evaluated using standard criteria. RESULTS: Twenty-four (24%) of the 102 BRCA1 mutation carriers experienced a pCR. The response rate varied widely with treatment: a pCR was observed in one (7%) of 14 women treated with cyclophosphamide, methotrexate, and fluorouracil (CMF); in two (8%) of 25 women treated with doxorubicin and docetaxel (AT); in 11 (22%) of 51 women treated with doxorubicin and cyclophosphamide (AC) or fluorouracil, doxorubicin, and cyclophosphamide (FAC), and in 10 (83%) of 12 women treated with cisplatin. CONCLUSION: A low rate of pCR was observed in women with breast cancer and a BRCA1 mutation who were treated with AT or CMF. A high rate of pCR was seen after treatment with cisplatin. An intermediate rate of PCR was associated with AC or FAC. The relative benefits of AC and platinum therapy need to be confirmed through follow-up of this and other cohorts. |
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Authors:
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Tomasz Byrski; Jacek Gronwald; Tomasz Huzarski; Ewa Grzybowska; Magdalena Budryk; Malgorzata Stawicka; Tomasz Mierzwa; Marek Szwiec; Rafal Wisniowski; Monika Siolek; Rebecca Dent; Jan Lubinski; Steven Narod |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-14 |
Journal Detail:
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Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: 28 ISSN: 1527-7755 ISO Abbreviation: J. Clin. Oncol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-18 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 375-9 Citation Subset: IM |
Affiliation:
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Department of Genetics andPathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Antineoplastic Agents / administration & dosage* Antineoplastic Combined Chemotherapy Protocols / administration & dosage Breast Neoplasms / drug therapy*, genetics Cisplatin / administration & dosage Cyclophosphamide / administration & dosage Doxorubicin / administration & dosage Female Fluorouracil / administration & dosage Genes, BRCA1 Humans Methotrexate / administration & dosage Middle Aged Neoadjuvant Therapy Registries Taxoids / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/AC protocol; 0/Antineoplastic Agents; 0/CAF protocol; 0/CMF regimen; 0/Taxoids; 114977-28-5/docetaxel; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 59-05-2/Methotrexate |
| Comments/Corrections | |
Comment In:
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J Clin Oncol. 2010 Jan 20;28(3):361-3
[PMID:
20008634
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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