| Pathologic changes and glucose homeostasis according to expression of human islet amyloid polypeptide in type 2 diabetic patients. | |
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MedLine Citation:
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PMID: 20421596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amount of amyloid detectable in islets varies, and is not always correlated with degree of beta-cell loss. It has been hypothesized that islet amyloid polypeptide (IAPP) aggregation causes beta-cell dysfunction. In this study, we investigated the relationship between IAPP expression and glucose homeostasis in pancreatectomized patients. Human pancreatic head tissues were collected from 46 pancreatic tumor patients. We divided the diabetic cases into two groups, patients with higher IAPP-expressing islets (DM-H) and patients with lower IAPP-expressing islets (DM-L), and compared both groups to patients with normal glucose tolerance (NGT). Interestingly, oral glucose tolerance test analyses showed that DM-L patients had significantly higher glucose levels and lower C-peptide levels than DM-H patients. Furthermore, the DM-H group showed a relative beta-cell volume similar to that of the NGT group, as well as a significantly higher relative beta-cell volume than the DM-L group. The DM-L group was significantly higher than the DM-H group, not only in the rates of replication and apoptosis, but also in the nuclear C/EBP homologous protein and the ratio of oligomer to IAPP. Thus, IAPP expression may not be an indicator of cell death induction. IAPP, including oligomer, may be an important determinant in the fate of islet beta-cells. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials. |
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Authors:
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Ji Young Park; Hee Sung No; You Ran Ahn; Seung Hoon Oh; Young Seok Kim; Sook Young Kim; Kee Taek Jang; Sun Wook Kim; Jae Hoon Chung; Yong Ki Min; Jin Seok Heo; Seong Ho Choi; Dong Wook Choi; Myung-Shik Lee; Moon Kyu Lee; Jae Hyeon Kim; Kwang-Won Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-26 |
Journal Detail:
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Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Volume: 58 ISSN: 1551-5044 ISO Abbreviation: J. Histochem. Cytochem. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-17 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9815334 Medline TA: J Histochem Cytochem Country: United States |
Other Details:
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Languages: eng Pagination: 731-40 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyloid / genetics, metabolism*, ultrastructure Blood Glucose / metabolism* Cell Proliferation Diabetes Mellitus, Type 2 / pathology* Female Gene Expression Glucagon / metabolism Glucose Tolerance Test Humans Islet Amyloid Polypeptide Islets of Langerhans / metabolism, pathology*, ultrastructure Male Middle Aged Pancreas / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/Blood Glucose; 0/Islet Amyloid Polypeptide; 9007-92-5/Glucagon |
| Comments/Corrections | |
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