| Pathogens and the placental fortress. | |
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MedLine Citation:
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PMID: 22169833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental infections are major causes of maternal and fetal disease. This review introduces a new paradigm for placental infections based on current knowledge of placental defenses and how this barrier can be breached. Transmission of pathogens from mother to fetus can occur at two sites of direct contact between maternal cells and specialized fetal cells (trophoblasts) in the human placenta: firstly, maternal immune and endothelial cells juxtaposed to extravillous trophoblasts in the uterine implantation site and secondly, maternal blood surrounding the syncytiotrophoblast (SYN). Recent findings suggest that the primary vulnerability is in the implantation site. We explore evidence that the placental SYN evolved as a defense against pathogens, and that inflammation-mediated spontaneous abortion may benefit mother and pathogen. |
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Authors:
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Jennifer R Robbins; Anna I Bakardjiev |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-12-12 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 15 ISSN: 1879-0364 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: 2012-05-11 Revised Date: 2012-05-21 |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 36-43 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, University of California, San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Septic
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immunology,
microbiology,
parasitology Bacterial Infections / immunology*, microbiology, pathology Female Humans Placenta / immunology*, microbiology, parasitology Pregnancy Pregnancy Complications, Infectious / immunology*, microbiology*, parasitology Pregnancy Complications, Parasitic / immunology*, parasitology* Protozoan Infections / immunology*, parasitology, pathology Trophoblasts / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI084928/AI/NIAID NIH HHS; R01 AI084928-02/AI/NIAID NIH HHS; R01 AI84929/AI/NIAID NIH HHS |
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