Document Detail

Pathogenicity and infectivity of Toxoplasma gondii oocysts for rats.
MedLine Citation:
PMID:  8973405     Owner:  NLM     Status:  MEDLINE    
Rats are considered to be 1 of the most resistant hosts for Toxoplasma gondii infection, but relative infectivity of T. gondii for rats is not known. Therefore, infectivity and pathogenicity of oocysts of the VEG strain of T. gondii were studied in Sprague Dawley weaned rats (approximately 130 g). Groups of 5 rats were each inoculated orally with 1 to 1 million infective oocysts. Three of the 5 rats fed 1 million oocysts died of acute toxoplasmosis between 6 and 9 days after ingesting oocysts; all other rats survived. Tissue cysts were found in brains of all rats fed > or = 10 oocysts and in 3 of 6 rats fed 1 oocyst. The average number of tissue cysts in brains of rats was 300, 180, 528, 600, 396, 1,200, and 2,650 in rats fed 1, 10, 100, 1,000, 10,000, 100,000 or 1 million oocysts, respectively. Microscopic lesions were seen in brains of all T. gondii-infected rats and the frequency of lesions was usually proportional to the dose. Antibodies (> or = 1:512) to T. gondii were detected in sera of all infected rats 29 days after ingestion of oocysts by the modified agglutination test, the commercially available latex agglutination test, and the indirect hemagglutination test.
J P Dubey
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of parasitology     Volume:  82     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-6     Citation Subset:  IM    
Parasite Biology and Epidemiology Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705-2350, USA.
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MeSH Terms
Agglutination Tests
Antibodies, Protozoan / blood
Brain / parasitology,  pathology
Disease Models, Animal*
Heart / parasitology
Hemagglutination Tests
Intestines / parasitology,  pathology
Latex Fixation Tests
Lung / parasitology,  pathology
Lymph Nodes / parasitology,  pathology
Mice / parasitology*
Rats, Sprague-Dawley / parasitology*
Species Specificity
Tongue / parasitology
Toxoplasma / immunology,  pathogenicity*
Toxoplasmosis, Animal / parasitology*
Reg. No./Substance:
0/Antibodies, Protozoan

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