Document Detail

Pathogenicity for horses of original Sagiyama virus, a member of the Getah virus group.
MedLine Citation:
PMID:  2847399     Owner:  NLM     Status:  MEDLINE    
Sagiyama virus is a member of the Getah virus group. Its pathogenicity for horses was examined. All the horses infected with the original 4 strains of Sagiyama virus (M6/Mag 33, Mag 121, Mag 132 and Mag 258) developed pyrexia ranging from 39.0 to 40.0 degrees C. Other clinical signs, characterized by eruptions, edema in the hind legs, enlargement of the submandibular lymph node and mild leukopenia, were also manifested. Viremia occurred 1-4 days post-inoculation (p.i.). Virus was recovered from spleen, liver, lung and various lymph nodes of a horse autopsied on Day 4 p.i. The maximum titer of virus (10(6.0) TCID50 g-1) was detected in the inguinal lymph node. Seroconversion was demonstrated in all the infected horses on Day 5 p.i. These clinical signs and virological findings were similar to those of horses infected naturally. The results indicate that Sagiyama virus has pathogenicity for horses and is similar to that of Getah virus.
T Kumanomido; M Kamada; R Wada; T Kenemaru; T Sugiura; Y Akiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary microbiology     Volume:  17     ISSN:  0378-1135     ISO Abbreviation:  Vet. Microbiol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-12-14     Completed Date:  1988-12-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  367-73     Citation Subset:  IM    
Equine Research Institute, Japan Racing Association, Tochigi.
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MeSH Terms
Alphavirus / pathogenicity*
Horse Diseases / blood,  microbiology*
Togaviridae Infections / blood,  microbiology,  veterinary*
Viremia / veterinary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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