Document Detail


Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis.
MedLine Citation:
PMID:  22443691     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute to demyelination. On the contrary, B cells have also been shown to have protective functions in that they play an essential role in the spontaneous recovery from EAE. In this review, we summarize studies conducted in a number of species demonstrating the conditions under which B cells are pathogenic in EAE. We also discuss the phenotype and anti-inflammatory mechanisms of regulatory B cells.
Authors:
Monica K Mann; Avijit Ray; Sreemanti Basu; Christopher L Karp; Bonnie N Dittel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-19
Journal Detail:
Title:  Autoimmunity     Volume:  45     ISSN:  1607-842X     ISO Abbreviation:  Autoimmunity     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-29     Completed Date:  2012-11-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  England    
Other Details:
Languages:  eng     Pagination:  388-99     Citation Subset:  IM    
Affiliation:
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201-2178, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / immunology
B-Lymphocyte Subsets / immunology,  metabolism
B-Lymphocytes / immunology*,  metabolism
B-Lymphocytes, Regulatory / immunology,  metabolism
Cytokines / biosynthesis,  immunology
Encephalomyelitis, Autoimmune, Experimental / etiology,  immunology*
Humans
Immunoglobulins / immunology
Grant Support
ID/Acronym/Agency:
R01 AI069358/AI/NIAID NIH HHS; R01 AI069358/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 0/Cytokines; 0/Immunoglobulins
Comments/Corrections

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