| Pathogenic factors involved in the development of irritable bowel syndrome: focus on a microbial role. | |
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MedLine Citation:
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PMID: 20937460 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Irritable bowel syndrome (IBS) is a symptom complex characterized by recurrent abdominal pain or discomfort, and accompanied by abnormal bowel habits, in the absence of any discernible organic abnormality. Its origin remains unclear, partly because multiple pathophysiologic mechanisms are likely to be involved. A significant proportion of patients develop IBS symptoms after an episode of gastrointestinal infection. In addition to gastrointestinal pathogens, recent evidence suggests that patients with IBS have abnormal composition and higher temporal instability of their intestinal microbiota. Because the intestinal microbiota is an important determinant of normal gut function and immunity, this instability may constitute an additional mechanism that leads to symptom generation and IBS. More importantly, a role for altered microbiota composition in IBS raises the possibility of therapeutic interventions through selective antibiotic or probiotic administration. The new concept of functional bowel diseases incorporates the bidirectional communication between the gut and the central nervous system (gut-brain axis), which may explain the multiple facets of IBS by linking emotional and cognitive centers of the brain with peripheral functioning of the gastrointestinal tract and vice versa. |
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Authors:
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Carolina M Bolino; Premysl Bercik |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infectious disease clinics of North America Volume: 24 ISSN: 1557-9824 ISO Abbreviation: Infect. Dis. Clin. North Am. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804508 Medline TA: Infect Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 961-75, ix Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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