Document Detail


Pathogenic Mechanisms Linking Periodontal Diseases With Adverse Pregnancy Outcomes.
MedLine Citation:
PMID:  22421445     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the last 2 decades, a large proportion of studies have focused on the relationship between maternal periodontal disease and poor obstetric outcomes. The aim of the present review is to summarize the current knowledge about human studies on the pathogenetic mechanisms linking periodontal diseases with adverse pregnancy outcomes. A search of the medical literature was conducted using NIH (National Institute of Health) Pubmed through April 2011. Articles were identified with the Medical Subject Heading (MeSH) and free text terms "small for gestational age (SGA)," "preeclampsia," "preterm labor," and "periodontal disease." Experimental human studies have shown that periodontal pathogens may disseminate toward placental and fetal tissues accompanied by an increase in inflammatory mediators in the placenta. As such, new inflammatory reactions within the placental tissues of the pregnant woman may occur, the physiological levels of prostaglandin E(2) (PGE(2)) and tumor necrosis factor-α (TNF-α) in the amniotic fluid may increase and eventually lead to premature delivery. Although many data from clinical trials suggest that periodontal disease may increase the adverse pregnancy outcome, the exact pathogenetic mechanism involved remains controversial. The findings explain the potential link between periodontal infections and adverse pregnancy outcomes. First, periodontal bacteria can directly cause infections both of the uteroplacenta and the fetus; second, systemic inflammatory changes induced by periodontal diseases can activate responses at the maternal-fetal interface. Of note, associative studies have produced different results in different population groups and no conclusive evidence has still been produced for the potential role of preventive periodontal care to reduce the risk factors of preterm birth.
Authors:
I Cetin; P Pileri; A Villa; S Calabrese; L Ottolenghi; S Abati
Related Documents :
21883065 - Egg contribution towards the diet of pregnant latinas.
12233865 - Monitoring of nitrite and n-nitrosamine levels in irradiated pork sausage.
25335995 - Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage.
22652045 - The breadth of the placental surface but not the length is associated with body size at...
15257825 - Effect of pgd on implantation and ongoing pregnancy rates in cases with predominantly m...
9828745 - Adverse neonatal effects of maternal labetalol treatment.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-14
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  -     ISSN:  1933-7205     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Variants in Follicle-Stimulating Hormone Receptor Gene in Infertile Brazilian Men and the Correlatio...
Next Document:  Mid-gestation ovine cardiomyocytes are vulnerable to mitotic suppression by thyroid hormone.