Document Detail

Pathogenetic role of increased nasal resistance in obese patients with obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  20109326     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of increased nasal resistance in obstructive sleep apnea syndrome (OSAS) remains controversial. The aim of this study was to examine the pathogenetic role of nasal obstruction in obese patients with OSAS.
METHODS: Patients with OSAS (n = 125) at a university hospital were divided into three groups according to body mass index (BMI): nonobese (BMI < 25 kg/m(2)), mildly obese (25 kg/m(2) < or = BMI < 30 kg/m(2)), and obese (BMI > or = 30 kg/m(2)). The subjects underwent nasopharyngoscopy, measurement of nasal resistance, and polysomnography.
RESULTS: We studied 42 nonobese, 47 mildly obese, and 36 obese patients with OSAS. Among the obese, but not the nonobese and mildly obese patients, we found significant correlations between the oxygen desaturation index (ODI) and bilateral nasal resistance (BNR; r = 0.412; p = 0.013), between the ODI and unilateral higher nasal resistance (UHNR; r = 0.413; p = 0.012), and between the apnea index and UHNR (r = 0.334; p = 0.046). Multiple regression analysis incorporating all patients showed that BMI (p < 0.001) and BNR (p = 0.033) were independently related to the ODI.
CONCLUSION: In obese patients with OSAS, increased nasal resistance could play an important pathogenetic role in hypoxemic apnea.
Mitsuhiko Tagaya; Seiichi Nakata; Fumihiko Yasuma; Akiko Noda; Mami Morinaga; Hidehito Yagi; Makoto Sugiura; Masaaki Teranishi; Tsutomu Nakashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of rhinology & allergy     Volume:  24     ISSN:  1945-8932     ISO Abbreviation:  Am J Rhinol Allergy     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-06-11     Revised Date:  2011-11-10    
Medline Journal Info:
Nlm Unique ID:  101490775     Medline TA:  Am J Rhinol Allergy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  IM    
Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
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MeSH Terms
Aged, 80 and over
Airway Resistance*
Middle Aged
Nasal Obstruction / complications*
Obesity / complications*
Risk Factors
Sleep Apnea, Obstructive / diagnosis,  etiology*,  physiopathology

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