Document Detail

Pathogenetic mechanisms of exercise-induced asthma and the refractory period.
MedLine Citation:
PMID:  3045523     Owner:  NLM     Status:  MEDLINE    
Exercise is a powerful stimulus to the development of asthma. In most asthmatic subjects the airways obstruction recovers spontaneously within 60 minutes, but in some subjects there is more prolonged airflow obstruction which requires bronchodilator treatment. Approximately 40-50% of subjects with EIA will show a refractory period of two to four hours after an initial exercise task, during which time an identical exercise task will evoke significantly less (less than 50%) bronchoconstriction. In some patients, particularly children, EIA will be followed three to nine hours later by a further episode of bronchospasm, termed the late asthmatic response. There remains considerable debate about the pathogenesis of EIA the refractory period and the late asthmatic response.
N G Belcher; S O'Hickey; J P Arm; T H Lee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  New England and regional allergy proceedings     Volume:  9     ISSN:  0742-2814     ISO Abbreviation:  N Engl Reg Allergy Proc     Publication Date:    1988 May-Jun
Date Detail:
Created Date:  1988-10-03     Completed Date:  1988-10-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306562     Medline TA:  N Engl Reg Allergy Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-201     Citation Subset:  IM    
Department of Medicine, Guy's Hospital, London, UK.
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MeSH Terms
Asthma / etiology*
Asthma, Exercise-Induced / etiology*
Physical Exertion
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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