| Pathogenetic implications of internuclear bridging in myelodysplastic syndrome. An Eastern Cooperative Oncology Group/Southwest Oncology Group Cooperative Study. | |
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MedLine Citation:
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PMID: 2804910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous morphologic features have been described in bone marrow and peripheral blood in myelodysplastic syndrome (MDS). We draw attention to a high incidence of a subtle morphologic feature, internuclear bridging (INB), not previously recognized as a morphologic feature in MDS. The occurrence of INB in MDS suggests an underlying abnormality of mitotic division that could explain the impaired production of hematopoietic cells, the addition and deletion cytogenetic changes, and the stepwise disease progression and cytogenetic progression characteristic of MDS. Lack of awareness that INB occurs in MDS may cause confusion of MDS and congenital dyserythropoietic anemia type I, a congenital process also characterized by INB. |
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Authors:
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D R Head; K Kopecky; J M Bennett; K Grenier; F S Morrison; K B Miller; M R Grever |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer Volume: 64 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1989-12-15 Completed Date: 1989-12-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2199-2202 Citation Subset: AIM; IM |
Affiliation:
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St. Jude Children's Research Hospital, Memphis, Tennessee. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow
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pathology*,
ultrastructure Cell Nucleus / pathology* Erythrocytes / pathology*, ultrastructure Humans Mitosis / physiology Myelodysplastic Syndromes / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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CA-11083/CA/NCI NIH HHS; CA-13238/CA/NCI NIH HHS; CA-37429/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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