Document Detail

Pathogenetic implication of interleukin-2 expressed in preeclamptic decidual tissues: a possible mechanism of deranged vasculature of the placenta associated with preeclampsia.
MedLine Citation:
PMID:  9272205     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The purpose of this study is to clarify whether IL-2 expressed in the decidua in preeclampsia affects the angiogenesis of the placenta. METHOD OF STUDY: We investigated the angiogenic substances released from human trophoblasts obtained from early pregnancy that had been pretreated with either IL-2, non-activated lymphocytes from peripheral blood mononuclear cells (PBMCs), decidual lymphocytes, or these lymphocytes activated by lymphokine (LAK cells). Angiogenic activity was determined by evaluating the ability of growth-promotion of cultured human microvascular endothelial cells (HMvECs) using MTT assay. RESULTS: Trophoblasts pretreated with IL-2 or non-activated lymphocytes, irrespective of their origin, released angiogenic factor similar to those without pretreatment. However, trophoblasts pretreated with LAK cells released less angiogenic factor compared with those without pretreatment. CONCLUSIONS: Interleukin-2 (IL-2) expressed in preeclamptic decidua might reduce the angiogenic substances arising from trophoblasts by inducing LAK-cells from decidual lymphocytes, which might be relevant to deranged vasculature of the placenta, a characteristic histology in preeclampsia.
Y Hamai; T Fujii; T Yamashita; S Kozuma; T Okai; Y Taketani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  38     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-17     Completed Date:  1997-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Angiogenesis Inducing Agents / metabolism*
Cell Division
Cells, Cultured
Chorionic Gonadotropin / analysis
Culture Media, Conditioned
Decidua / metabolism*
Endothelium, Vascular / cytology,  immunology
Estradiol / analysis
Interleukin-2 / pharmacology*
Killer Cells, Lymphokine-Activated / immunology
Lymphocyte Activation
Neovascularization, Physiologic
Placenta / blood supply*
Placental Lactogen / analysis
Pre-Eclampsia / etiology,  immunology*
Pregnancy Trimester, First
Progesterone / analysis
Trophoblasts / cytology,  immunology
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Chorionic Gonadotropin; 0/Culture Media, Conditioned; 0/Interleukin-2; 50-28-2/Estradiol; 57-83-0/Progesterone; 9035-54-5/Placental Lactogen

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