Document Detail


Pathogenesis of vascular anomalies.
MedLine Citation:
PMID:  21095468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular anomalies are localized defects of vascular development. Most of them occur sporadically (ie, there is no familial history of lesions, yet in a few cases clear inheritance is observed). These inherited forms are often characterized by multifocal lesions that are mainly small in size and increase in number with patients' age. The authors review the known (genetic) causes of vascular anomalies and call attention to the concept of Knudson's double-hit mechanism to explain incomplete penetrance and large clinical variation in expressivity observed in inherited vascular anomalies. The authors also discuss the identified pathophysiological pathways involved in vascular anomalies and how it has opened the doors toward a more refined classification of vascular anomalies and the development of animal models that can be tested for specific molecular therapies.
Authors:
Laurence M Boon; Fanny Ballieux; Miikka Vikkula
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in plastic surgery     Volume:  38     ISSN:  1558-0504     ISO Abbreviation:  Clin Plast Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0424767     Medline TA:  Clin Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-19     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques Universitaires St Luc, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Capillaries / abnormalities
Hemangioma / etiology*,  physiopathology
Humans
Lymphatic Abnormalities
Lymphedema
Vascular Malformations / etiology*,  physiopathology
Veins / abnormalities
Grant Support
ID/Acronym/Agency:
P01 AR048564/AR/NIAMS NIH HHS; P01 AR048564-07/AR/NIAMS NIH HHS; P01 AR048564-08/AR/NIAMS NIH HHS
Comments/Corrections

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