| Pathogenesis of vascular anomalies. | |
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MedLine Citation:
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PMID: 21095468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular anomalies are localized defects of vascular development. Most of them occur sporadically (ie, there is no familial history of lesions, yet in a few cases clear inheritance is observed). These inherited forms are often characterized by multifocal lesions that are mainly small in size and increase in number with patients' age. The authors review the known (genetic) causes of vascular anomalies and call attention to the concept of Knudson's double-hit mechanism to explain incomplete penetrance and large clinical variation in expressivity observed in inherited vascular anomalies. The authors also discuss the identified pathophysiological pathways involved in vascular anomalies and how it has opened the doors toward a more refined classification of vascular anomalies and the development of animal models that can be tested for specific molecular therapies. |
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Authors:
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Laurence M Boon; Fanny Ballieux; Miikka Vikkula |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinics in plastic surgery Volume: 38 ISSN: 1558-0504 ISO Abbreviation: Clin Plast Surg Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-04-05 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0424767 Medline TA: Clin Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 7-19 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques Universitaires St Luc, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Capillaries
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abnormalities Hemangioma / etiology*, physiopathology Humans Lymphatic Abnormalities Lymphedema Vascular Malformations / etiology*, physiopathology Veins / abnormalities |
| Grant Support | |
ID/Acronym/Agency:
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P01 AR048564/AR/NIAMS NIH HHS; P01 AR048564-07/AR/NIAMS NIH HHS; P01 AR048564-08/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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