Document Detail

Pathogenesis of vascular anomalies.
MedLine Citation:
PMID:  21095468     Owner:  NLM     Status:  MEDLINE    
Vascular anomalies are localized defects of vascular development. Most of them occur sporadically (ie, there is no familial history of lesions, yet in a few cases clear inheritance is observed). These inherited forms are often characterized by multifocal lesions that are mainly small in size and increase in number with patients' age. The authors review the known (genetic) causes of vascular anomalies and call attention to the concept of Knudson's double-hit mechanism to explain incomplete penetrance and large clinical variation in expressivity observed in inherited vascular anomalies. The authors also discuss the identified pathophysiological pathways involved in vascular anomalies and how it has opened the doors toward a more refined classification of vascular anomalies and the development of animal models that can be tested for specific molecular therapies.
Laurence M Boon; Fanny Ballieux; Miikka Vikkula
Related Documents :
2488948 - Stereotactic resection of pediatric vascular malformations.
12203808 - Angiofibroma of the larynx: report of a case with clinical and pathologic literature re...
6572878 - Treatment of maxillary hemangioma with a sclerosing agent.
16008648 - Case of non-involuting congenital haemangioma.
6540418 - Monocular elevation paresis caused by an ipsilateral lesion.
22551398 - The many faces of acinic cell carcinomas of the salivary glands: a study of 40 cases re...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in plastic surgery     Volume:  38     ISSN:  1558-0504     ISO Abbreviation:  Clin Plast Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-05     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0424767     Medline TA:  Clin Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-19     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Capillaries / abnormalities
Hemangioma / etiology*,  physiopathology
Lymphatic Abnormalities
Vascular Malformations / etiology*,  physiopathology
Veins / abnormalities
Grant Support
P01 AR048564/AR/NIAMS NIH HHS; P01 AR048564/AR/NIAMS NIH HHS; P01 AR048564-07/AR/NIAMS NIH HHS; P01 AR048564-08/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vascular anomalies: current overview of the field.
Next Document:  Diagnostic imaging of vascular anomalies.