Document Detail

Pathogenesis of varices in schistosomal portal hypertension.
MedLine Citation:
PMID:  8281865     Owner:  NLM     Status:  MEDLINE    
Patients with schistosomiasis and portal hypertension have significantly lower levels of hydroxyproline in their saphenous veins and anterior rectus sheaths than do individuals without schistosomal hepatic fibrosis. The stomach of patients with schistosomal portal hypertension demonstrates an increased number of lymphatics by lymphangiography. The disrupted lymph node architecture in these patients could be partially responsible for dilation, tortuosity, and retrograde lymph flow in the gastric lymphatics. These histological and lymphangiographic findings could be attributed to the effect of venous and patients with decompensated schistosomal portal hypertension revealed edema of the entire esophageal wall with lymphatic dilation and tortuosity. Based upon these data, we suggest that the varices that develop in patients with schistosomal portal hypertension occur as a consequence of an increased portal venous pressure together with acquired lymphangiectasia as well as an intrinsic weakness of the walls of the portosystemic venous channels.
A Aboul-Enein; S Arafa; M Sakr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  39     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-02-17     Completed Date:  1994-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  AIM; IM    
Department of Surgery, School of Medicine, University of Alexandria, Egypt.
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MeSH Terms
Collagen / biosynthesis*
Esophageal and Gastric Varices / etiology*,  pathology
Esophagus / pathology
Hydroxyproline / analysis
Hypertension, Portal / parasitology*,  pathology
Liver Diseases, Parasitic / complications*
Lymphangiectasis / pathology
Lymphatic System / pathology
Rectus Abdominis / chemistry
Saphenous Vein / chemistry
Schistosomiasis / complications*
Stomach / pathology
Reg. No./Substance:
51-35-4/Hydroxyproline; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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