| Pathogenesis and treatment of undescended testes. | |
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MedLine Citation:
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PMID: 6133752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired intrauterine gonadotropin secretion was the cause of cryptorchidism in 78% of cryptorchid boys studied. On the one hand, this impairment implied the underdevelopment of the epididymis and thus the cryptorchid state of the gonad. On the other hand, the histological alterations of the testis, due to impaired gonadotropin secretion were Leydig cell atrophy and an impairment in the number of the germ cells. The secondary damage, due to the unfavorable position, started during the second year of life. To avoid this damage, early treatment is highly recommended. Hormonal treatment with GnRH is the treatment of first choice. This treatment was successful in 60% of cryptorchid boys. An additional treatment of nonresponders with low doses of hCG increased the overall success rate to 80%. Six months after treatment, 14.5% of those successfully treated suffered a relapse. |
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Authors:
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F Hadziselimović |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatrics Volume: 139 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 255-65 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Child Child, Preschool Chorionic Gonadotropin / therapeutic use* Cryptorchidism / drug therapy*, etiology Epididymis / embryology Gonadotropin-Releasing Hormone / therapeutic use* Humans Infant Infant, Newborn Leydig Cells / pathology Male Mice Recurrence Testis / embryology, secretion Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 33515-09-2/Gonadotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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