Document Detail


Pathogenesis and treatment of undescended testes.
MedLine Citation:
PMID:  6133752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired intrauterine gonadotropin secretion was the cause of cryptorchidism in 78% of cryptorchid boys studied. On the one hand, this impairment implied the underdevelopment of the epididymis and thus the cryptorchid state of the gonad. On the other hand, the histological alterations of the testis, due to impaired gonadotropin secretion were Leydig cell atrophy and an impairment in the number of the germ cells. The secondary damage, due to the unfavorable position, started during the second year of life. To avoid this damage, early treatment is highly recommended. Hormonal treatment with GnRH is the treatment of first choice. This treatment was successful in 60% of cryptorchid boys. An additional treatment of nonresponders with low doses of hCG increased the overall success rate to 80%. Six months after treatment, 14.5% of those successfully treated suffered a relapse.
Authors:
F Hadziselimović
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  139     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  255-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Child
Child, Preschool
Chorionic Gonadotropin / therapeutic use*
Cryptorchidism / drug therapy*,  etiology
Epididymis / embryology
Gonadotropin-Releasing Hormone / therapeutic use*
Humans
Infant
Infant, Newborn
Leydig Cells / pathology
Male
Mice
Recurrence
Testis / embryology,  secretion
Time Factors
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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