| Pathogenesis and therapy of focal segmental glomerulosclerosis: an update. | |
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MedLine Citation:
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PMID: 21110043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Focal and segmental glomerulosclerosis (FSGS) is an important cause of steroid-resistant nephrotic syndrome in adults and children. It is responsible for 5-20% of all cases of end-stage kidney disease (ESKD) in the United States. The pathogenesis of FSGS has not been fully elucidated; however, data from molecular studies of familial cases in the last two decades suggest that FSGS is a defect of the podocyte. The therapeutic agents available for treatment of FSGS are not very effective and only a small percentage of affected individuals will achieve complete remission. Recent data from molecular biology and molecular genetics has provided insight into the mechanisms of action of old agents and also identification of other novel therapeutic targets. This review focuses on recent advances in the molecular pathogenesis of FSGS and currently available therapeutic agents as well as potential novel therapies. |
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Authors:
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Rasheed Gbadegesin; Peter Lavin; John Foreman; Michelle Winn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-11-26 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 26 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-05-20 Completed Date: 2011-09-16 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1001-15 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. rasheed.gbadegesin@duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Genetic Predisposition to Disease Glomerulosclerosis, Focal Segmental / classification, etiology*, pathology, therapy* Humans Immunosuppressive Agents / therapeutic use* Kidney / pathology* Podocytes / pathology Risk Factors Stem Cell Transplantation* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K08 DK082495/DK/NIDDK NIH HHS; K08 DK082495-03/DK/NIDDK NIH HHS; K08DK082495-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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