Document Detail


Pathogenesis and therapy of focal segmental glomerulosclerosis: an update.
MedLine Citation:
PMID:  21110043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Focal and segmental glomerulosclerosis (FSGS) is an important cause of steroid-resistant nephrotic syndrome in adults and children. It is responsible for 5-20% of all cases of end-stage kidney disease (ESKD) in the United States. The pathogenesis of FSGS has not been fully elucidated; however, data from molecular studies of familial cases in the last two decades suggest that FSGS is a defect of the podocyte. The therapeutic agents available for treatment of FSGS are not very effective and only a small percentage of affected individuals will achieve complete remission. Recent data from molecular biology and molecular genetics has provided insight into the mechanisms of action of old agents and also identification of other novel therapeutic targets. This review focuses on recent advances in the molecular pathogenesis of FSGS and currently available therapeutic agents as well as potential novel therapies.
Authors:
Rasheed Gbadegesin; Peter Lavin; John Foreman; Michelle Winn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-11-26
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  26     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-20     Completed Date:  2011-09-16     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1001-15     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. rasheed.gbadegesin@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Genetic Predisposition to Disease
Glomerulosclerosis, Focal Segmental / classification,  etiology*,  pathology,  therapy*
Humans
Immunosuppressive Agents / therapeutic use*
Kidney / pathology*
Podocytes / pathology
Risk Factors
Stem Cell Transplantation*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
K08 DK082495/DK/NIDDK NIH HHS; K08 DK082495-03/DK/NIDDK NIH HHS; K08DK082495-01/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents
Comments/Corrections

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