| Pathogenesis of sodium and water retention in high-output and low-output cardiac failure, nephrotic syndrome, cirrhosis, and pregnancy (2) | |
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MedLine Citation:
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PMID: 3050523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article has analyzed the pathogenesis of sodium and water retention in several circumstances. The initiator of retention has been proposed to be either a fall in cardiac output (e.g., low-output cardiac failure and vasoconstrictor hypovolemic nephrotic syndrome) or peripheral arterial vasodilatation (e.g., high-output cardiac failure, cirrhosis, arteriovenous fistula, and pregnancy). In the only state discussed, in which the kidney is diseased and not merely responding to extrarenal reflexes--i.e., nephrotic syndrome--intrarenal mechanisms may predominate and lead to expansion of the arterial vascular tree and suppression of the renin-angiotensin-aldosterone system (i.e., hypervolemic nephrotic syndrome). Otherwise, when kidneys are healthy, either a fall in cardiac output or peripheral arterial vasodilatation may diminish arterial vascular filling and thereby initiate a series of hemodynamic and hormonal events that result in renal sodium and water retention (Fig. 7). Finally, the approach presented in this article should be considered to be a vantage point from which to evaluate states of sodium and water retention, but not to be an exclusive position. |
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Authors:
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R W Schrier |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The New England journal of medicine Volume: 319 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-11-15 Completed Date: 1988-11-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1127-34 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Colorado School of Medicine, Denver 80262. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Water / metabolism* Cardiac Output Female Heart Failure / metabolism* Humans Liver Cirrhosis / metabolism Nephrotic Syndrome / metabolism* Pregnancy Pregnancy Complications / metabolism Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 1989 Jun 8;320(23):1561-2
[PMID:
2725590
]
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Erratum In:
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N Engl J Med 1989 Mar 9;320(10):676 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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