| Pathogenesis of sialadenosis: possible role of functionally deficient myoepithelial cells. | |
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MedLine Citation:
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PMID: 20580282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The pathogenesis of acinar enlargement in sialadenosis is obscure. As myoepithelial cells had been reported to show degenerative changes, we decided to investigate the possible role of functionally deficient myoepithelial cells in the development of sialadenosis. STUDY DESIGN: This study was a morphometric analysis of glands immunohistochemically stained for CK14, alpha-actin, and Ki67 in 10 cases of sialadenosis and 11 normal parotids. RESULTS: In sialadenosis, acini were much larger; there was a minor decrease in the density of the distribution of myoepithelial cells stained for CK14 and a major decrease in the density of the distribution and thickness of the myofilament component of myoepithelial cells stained for alpha-actin; and the proliferation of acinar and myoepithelial cells was reduced. CONCLUSIONS: Our results demonstrate a major loss and thinning of the myofilament component of the myoepithelial cells and thereby a loss of mechanical support for the acini in sialadenosis. This possibly allows acinar cells to expand as secretory granules accumulate intracellularly to produce the great acinar enlargement. This functional myoepithelial insufficiency is possibly a consequence of an autonomic neuropathy secondary to severe metabolic or hormonal disorders. |
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Authors:
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Stephan Ihrler; Christian Rath; Pamela Zengel; Thomas Kirchner; John D Harrison; Christoph Weiler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-26 |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 110 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-11-16 Revised Date: 2011-09-21 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 218-23 Citation Subset: D; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Institute of Pathology, Ludwig Maximilian University, Munich, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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analysis Adult Autonomic Nervous System Diseases / complications* Case-Control Studies Epithelial Cells / pathology, physiology Female Humans Keratin-14 / analysis Ki-67 Antigen Male Microfilaments / pathology Middle Aged Muscle Cells / pathology, physiology Parotid Diseases / etiology*, pathology* Secretory Vesicles / pathology |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Keratin-14; 0/Ki-67 Antigen |
| Comments/Corrections | |
Comment In:
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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):286; author reply 287
[PMID:
21546283
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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