Document Detail


Pathogenesis of sialadenosis: possible role of functionally deficient myoepithelial cells.
MedLine Citation:
PMID:  20580282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The pathogenesis of acinar enlargement in sialadenosis is obscure. As myoepithelial cells had been reported to show degenerative changes, we decided to investigate the possible role of functionally deficient myoepithelial cells in the development of sialadenosis.
STUDY DESIGN: This study was a morphometric analysis of glands immunohistochemically stained for CK14, alpha-actin, and Ki67 in 10 cases of sialadenosis and 11 normal parotids.
RESULTS: In sialadenosis, acini were much larger; there was a minor decrease in the density of the distribution of myoepithelial cells stained for CK14 and a major decrease in the density of the distribution and thickness of the myofilament component of myoepithelial cells stained for alpha-actin; and the proliferation of acinar and myoepithelial cells was reduced.
CONCLUSIONS: Our results demonstrate a major loss and thinning of the myofilament component of the myoepithelial cells and thereby a loss of mechanical support for the acini in sialadenosis. This possibly allows acinar cells to expand as secretory granules accumulate intracellularly to produce the great acinar enlargement. This functional myoepithelial insufficiency is possibly a consequence of an autonomic neuropathy secondary to severe metabolic or hormonal disorders.
Authors:
Stephan Ihrler; Christian Rath; Pamela Zengel; Thomas Kirchner; John D Harrison; Christoph Weiler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-26
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  110     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-11-16     Revised Date:  2011-09-21    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  D; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Affiliation:
Institute of Pathology, Ludwig Maximilian University, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Actins / analysis
Adult
Autonomic Nervous System Diseases / complications*
Case-Control Studies
Epithelial Cells / pathology,  physiology
Female
Humans
Keratin-14 / analysis
Ki-67 Antigen
Male
Microfilaments / pathology
Middle Aged
Muscle Cells / pathology,  physiology
Parotid Diseases / etiology*,  pathology*
Secretory Vesicles / pathology
Chemical
Reg. No./Substance:
0/Actins; 0/Keratin-14; 0/Ki-67 Antigen
Comments/Corrections
Comment In:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):286; author reply 287   [PMID:  21546283 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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