Document Detail

Pathogenesis of reticuloendotheliosis virus infection in ducks.
MedLine Citation:
PMID:  6316895     Owner:  NLM     Status:  MEDLINE    
A new isolate of reticuloendotheliosis virus (REV) from ducks, RU-1, was used to experimentally infect white pekin ducks. Embryonal or neonatal infection usually resulted in persistent viremias, no REV antibody development, and inability to mount antibody responses against bovine serum albumin (BSA) or sheep red blood cells (SRBC). In contrast, infection at 21 days of age resulted in transient viremias, which terminated coincident with REV antibody development. These ducks remained persistently infected, however, based on virus isolations from peripheral blood lymphocytes. Ducks infected at that age were immunologically competent against BSA and SRBC unless they had been embryonally bursectomized, in which case they behaved virologically and immunologically like those infected at an early age. Bursectomy by itself did not prevent responses against the antigens. Total mortality during 4- or 6-month experimental periods ranged from 80 to 100% in REV-infected groups, regardless of age at infection, route of exposure, or whether the ducks were intact or bursectomized. Most deaths were from non-neoplastic conditions (stunting, bacterial infections), but 17 of 69 (25%) infected ducks developed a variety of neoplasms, including lymphosarcomas, histiocytic sarcomas, and spindle-cell sarcomas.
J Li; B W Calnek; K A Schat; D L Graham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Avian diseases     Volume:  27     ISSN:  0005-2086     ISO Abbreviation:  Avian Dis.     Publication Date:    1983 Oct-Dec
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370617     Medline TA:  Avian Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1090-105     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / biosynthesis
Fluorescent Antibody Technique
Neoplasms / pathology,  veterinary
Neutralization Tests
Poultry Diseases / etiology*,  immunology,  pathology
Reticuloendotheliosis virus / growth & development*,  immunology,  isolation & purification
Retroviridae / growth & development*
Tumor Virus Infections / etiology,  immunology,  veterinary*
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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