| Pathogenesis of preeclampsia. | |
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MedLine Citation:
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PMID: 20078220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preeclampsia is a systemic syndrome that occurs in 3 to 5% of pregnant women and classically manifests as new-onset hypertension and proteinuria after 20 weeks of gestation. Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. The only known cure is delivery of the placenta. Recent discoveries, however, have led to important advances in understanding the pathogenesis of the condition. Placental antiangiogenic factors are upregulated and disrupt the maternal endothelium. This change in the normal angiogenic balance toward an antiangiogenic state can result in hypertension, proteinuria, glomerular endotheliosis, HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, and cerebral edema-the clinical signs of preeclampsia and eclampsia. The regulation of these antiangiogenic factors in the placenta is unknown. The recent discoveries of upregulated antiangiogenic factors provide promise for future testing to predict and diagnose preeclampsia as well as therapeutic targets for amelioration of the clinical disease. |
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Authors:
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Brett C Young; Richard J Levine; S Ananth Karumanchi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Annual review of pathology Volume: 5 ISSN: 1553-4014 ISO Abbreviation: Annu Rev Pathol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-18 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101275111 Medline TA: Annu Rev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 173-92 Citation Subset: IM |
Affiliation:
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Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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physiology* Endothelium / physiopathology Female Humans Ischemia / physiopathology Placenta / blood supply, physiology Pre-Eclampsia / etiology*, physiopathology* Pregnancy Up-Regulation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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