Document Detail

Pathogenesis and pathology of blackleg in ruminants: the role of toxins and neuraminidase. A short review.
MedLine Citation:
PMID:  14714738     Owner:  NLM     Status:  MEDLINE    
There is no consensus on the pathogenesis of blackleg infection that occurs in ruminants, but toxins and neuraminidase produced by Clostridium chauvoei are believed to play a significant role in the pathogenesis of the disease. This paper provides an update on the role of toxins and neuraminidase in the pathogenesis and pathology of the disease. The use of neuraminidase inhibitors to manage clinical blackleg infections is therefore an alternative therapeutic protocol that should be thoroughly investigated. It is suggested that in vivo clinical trials should be carried out to determine the mechanism of action and clinical efficacy of neuraminidase inhibitors.
N M Useh; A J Nok; K A N Esievo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Veterinary quarterly     Volume:  25     ISSN:  0165-2176     ISO Abbreviation:  Vet Q     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-12     Completed Date:  2004-01-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7909485     Medline TA:  Vet Q     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
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MeSH Terms
Bacterial Toxins
Cattle Diseases / microbiology*,  pathology
Clostridium / enzymology,  pathogenicity*
Clostridium Infections / microbiology,  veterinary*
Muscle, Skeletal / microbiology,  pathology
Reg. No./Substance:
0/Bacterial Toxins; EC

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