| Pathogenesis and pathology of blackleg in ruminants: the role of toxins and neuraminidase. A short review. | |
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MedLine Citation:
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PMID: 14714738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is no consensus on the pathogenesis of blackleg infection that occurs in ruminants, but toxins and neuraminidase produced by Clostridium chauvoei are believed to play a significant role in the pathogenesis of the disease. This paper provides an update on the role of toxins and neuraminidase in the pathogenesis and pathology of the disease. The use of neuraminidase inhibitors to manage clinical blackleg infections is therefore an alternative therapeutic protocol that should be thoroughly investigated. It is suggested that in vivo clinical trials should be carried out to determine the mechanism of action and clinical efficacy of neuraminidase inhibitors. |
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Authors:
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N M Useh; A J Nok; K A N Esievo |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Veterinary quarterly Volume: 25 ISSN: 0165-2176 ISO Abbreviation: Vet Q Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-01-12 Completed Date: 2004-01-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7909485 Medline TA: Vet Q Country: Netherlands |
Other Details:
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Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
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Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria. nickuseh@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Toxins Cattle Cattle Diseases / microbiology*, pathology Clostridium / enzymology, pathogenicity* Clostridium Infections / microbiology, veterinary* Muscle, Skeletal / microbiology, pathology Neuraminidase |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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