| Pathogenesis of one-kidney, one-clip hypertension in rats after renal denervation. | |
MedLine Citation:
|
PMID: 6377927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study examines the role of the renal nerves in the chronic and early developmental stages of one-kidney, one-clip (1K-1C) Goldblatt hypertension. Groups of uninephrectomized Sprague-Dawley rats underwent renal artery constriction with a clip of an internal diameter of 0.23 mm (groups 1 and 3) or 0.40 mm (groups 2 and 4) to produce severe or moderate hypertension. Two weeks later, groups 1 and 2 were subjected to renal denervation and groups 3 and 4 were denervated 6 and 7 wk after clipping, respectively. In all four groups, hypertension remained unchanged during the subsequent 2 wk after denervation. To study further the effects of renal denervation during the early onset of hypertension, groups 5, 6, and 7 received the smaller (0.23 mm) clip after uninephrectomy. Groups 5 and 6 were renal denervated immediately before clipping; group 7 was not denervated. In groups 6 and 7 the renin-angiotensin system was blocked with a continuous infusion of the converting-enzyme inhibitor captopril for 24 h before and 15 days after clipping. In group 5, renal denervation did not prevent a prompt and severe rise in the systolic blood pressure. In groups 6 and 7, infusion of captopril prevented the hypertension only during the first 4 days after clipping; at no time was there a difference in the systolic blood pressure curves of groups 6 and 7 during or after captopril infusion. These data demonstrate that regardless of the severity and duration of hypertension, renal denervation failed to attenuate either the development or the maintenance of 1K-1C Goldblatt hypertension in the rat. Thus the present results fail to provide support for the concept that the renal nerves modulate the hypertension in this experimental model. |
Authors:
|
D Villarreal; R H Freeman; J O Davis; G Garoutte; W D Sweet |
Related Documents
:
|
7365887 - Elevated pressure in the left renal vein in patients with varicocele: preliminary obser... 11561217 - Effect of valsartan on angiotensin ii- and vasopressin-degrading activities in the kidn... 975457 - The effect of an acute increase in renal perfusion pressure on sodium transport in the ... 3259447 - Regional hemodynamic responses to central administration of corticotropin-releasing fac... 1391177 - Effects of atherosclerosis on mean and daily variation of arterial pressure in consciou... 7570947 - Surfactant dysfunction in lung preservation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 247 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Jul |
Date Detail:
|
Created Date: 1984-08-17 Completed Date: 1984-08-17 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H61-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Captopril / pharmacology Denervation Hypertension, Renovascular / etiology* Kidney / innervation* Male Rats Rats, Inbred Strains Renin-Angiotensin System / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
|
62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vasomotor projections from the anteroventral third ventricle (AV3V) region.
Next Document: Characterization of the renin-angiotensin system in the turtle Pseudemys scripta.