Document Detail

Pathogenesis of neonatal lung lesions induced by artificial ventilation: evidence against the role of barotrauma.
MedLine Citation:
PMID:  6894337     Owner:  NLM     Status:  MEDLINE    
Premature newborn rabbits, delivered on day 27 of gestation, were ventilated for 10 min with a standardized peak pressure of 35 cm H2O, with or without previous instillation of natural surfactant into the airways. Lung-thorax compliance and stability were significantly enhanced in surfactant-treated fetuses. Although these fetuses were greatly overventilated, their tendency to develop bronchiolar epithelial lesions was significantly reduced in comparison with controls; this was verified by light as well as electron microscopy. Our findings argue against barotrauma as the cause of bronchiolar epithelial lesions during artificial ventilation, and favor the concept that these lesions reflect an abnormal expansion pattern due to surfactant deficiency.
R Nilsson; G Grossmann; B Robertson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  40     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1980  
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  218-25     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology*
Bronchi / ultrastructure
Lung / physiology*,  ultrastructure
Lung Compliance
Microscopy, Electron
Pulmonary Surfactants / physiology
Respiration, Artificial / adverse effects*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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