Document Detail

Pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament.
MedLine Citation:
PMID:  12450279     Owner:  NLM     Status:  MEDLINE    
OBJECT: The goal of this study was to clarify the pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament (OPLL) based on the relationship between static compression factors and dynamic factors. METHODS: There was a total of 247 patients, including 167 patients who were conservatively followed for a mean of 11 years and 2 months and 80 patients who had myelopathy at initial consultation and underwent surgery. The changes in clinical symptoms associated with OPLL in the cervical spine were examined periodically. During the natural course of OPLL in the cervical spine, 37 (22%) of 167 patients developed or suffered aggravated spinal symptoms. All of the patients with a space available for the spinal cord (SAC) less than 6 mm suffered myelopathy, whereas the patients with an SAC diameter of 14 mm or greater did not. No correlation was found between the presence or absence of myelopathy in patients whose SAC diameter ranged from 6 mm to less than 14 mm. In patients with myelopathy whose minimal SAC diameter ranged from 6 mm to less than 14 mm, the range of motion of the cervical spine was significantly greater. CONCLUSIONS: These results indicate that pathological compression by the ossified ligament above a certain critical point may be the most significant factor in inducing myelopathy, whereas below that point dynamic factors may be largely involved in inducing myelopathy.
Shunji Matsunaga; Makoto Kukita; Kyoji Hayashi; Reiko Shinkura; Chihaya Koriyama; Takashi Sakou; Setsuro Komiya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  96     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2002-12-13     Revised Date:  2005-04-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  168-72     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Cervical Vertebrae / physiopathology
Disease Progression
Middle Aged
Orthopedic Procedures
Ossification of Posterior Longitudinal Ligament / complications*,  therapy
Prospective Studies
Range of Motion, Articular
Spinal Cord Diseases / etiology*,  physiopathology

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