Document Detail

Pathogenesis and management of peripartum coagulopathic calamities (disseminated intravascular coagulation and amniotic fluid embolism).
MedLine Citation:
PMID:  23452737     Owner:  NLM     Status:  In-Data-Review    
Acute coagulopathic peripartum calamities are relatively rare but contribute importantly to maternal morbidity and mortality in the Western world. Abruptio placenta, amniotic fluid embolism, and retained fetal or placental material may lead to fulminant intravascular activation of coagulation which results in thromboembolic complications and consumption coagulopathy causing severe hemorrhage. The central underlying pathophysiological pathway in the coagulopathy associated with these syndromes is the occurrence of tissue factor, released from the placenta and amniotic fluid, in the circulation, in combination with low levels of physiological anticoagulant factors during pregnancy. The diagnosis of DIC may be made trough conventional composite scoring systems employing routine coagulation tests, whereas for the diagnosis of amniotic fluid embolism measurement of insulin like growth factor binding protein-1 seems promising. Therapy is aimed at removing the precipitating factor combined with supportive adjunctive treatment options.
Marcel Levi
Related Documents :
10064317 - Biotin status: which are valid indicators and how do we know?
19005017 - Central cholinergic mechanisms mediate swallowing, renal excretion, and c-fos expressio...
2002977 - Sequential invasive assessment of fetal renal function and the intrauterine treatment o...
2751957 - The excretion of 5-oxoproline in urine, as an index of glycine status, during normal pr...
8459967 - Fetal renal artery flow velocity waveforms in normal pregnancies and pregnancies compli...
9049037 - Effect of sperm preincubation time on gift pregnancy outcome.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  131 Suppl 1     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S32-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antiphospholipid syndrome: Looking for a refocusing.
Next Document:  Intraventricular hemorrhage in preterm infants and coagulation - Ambivalent perspectives?