Document Detail


Pathogenesis of malaria-associated acute respiratory distress syndrome.
MedLine Citation:
PMID:  23742967     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an increasingly reported, often lethal, and incompletely understood complication of malaria. We discuss and compare the pathogenesis of MA-ARDS in patients and in different murine models, including recent models without cerebral involvement, and summarize the roles of different leukocyte subclasses, adhesion molecules, cytokines, and chemokines. In patients as well as in mice, severe edema and impaired gas exchange are associated with abundant inflammatory infiltrates consisting of mainly mononuclear cells and parasite sequestration, and the pathogenesis appears different from cerebral malaria (CM). Experimental anti-inflammatory interventions are successful in mice and remain to be validated in patients.
Authors:
Philippe E Van den Steen; Katrien Deroost; Julie Deckers; Evelien Van Herck; Sofie Struyf; Ghislain Opdenakker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-3
Journal Detail:
Title:  Trends in parasitology     Volume:  -     ISSN:  1471-5007     ISO Abbreviation:  Trends Parasitol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966034     Medline TA:  Trends Parasitol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: philippe.vandensteen@rega.kuleuven.be.
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