Document Detail


Pathogenesis of lumbosacral lipoma: a test of the "premature dysjunction" theory.
MedLine Citation:
PMID:  11359100     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or "premature dysjunction" theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburger and Hamilton stage 12 or 13 chick embryos. Among 35 embryos evaluated, 15 showed abnormal findings, and of these one showed findings which suggested lumbosacral lipoma: a back lump, blending of the neuroepithelium and mesenchyme through indistinct basement membrane and vertebral body abnormalities. The other 14 embryos showed abnormalities including blunt tails, open neural tube defects, incomplete closure of the dorsal neuroepithelium with intact skin, skin dimples, disorganized gray matter, scoliosis, ectopic neuroepithelium and an accessory spinal cord. The results revealed that the incision of the unilateral neural fold in the early chick embryo may produce a lesion suggestive of lumbosacral lipoma, a finding which supports the premature dysjunction theory. This method needs further refinement to overcome technical difficulties, high mortality, and a low yield before being adopted as an experimental model for lumbosacral lipoma.
Authors:
Y C Li; S H Shin; B K Cho; M S Lee; Y J Lee; S K Hong; K C Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurosurgery     Volume:  34     ISSN:  1016-2291     ISO Abbreviation:  Pediatr Neurosurg     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-18     Completed Date:  2001-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114967     Medline TA:  Pediatr Neurosurg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  124-30     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Division of Pediatric Neurosurgery and Laboratory for Fetal Medicine Research, Clinical Research Institute, Seoul National University Hospital, 28 Yongon-dong, Chongnu-ku, Seoul 110-744, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Lipoma / complications*,  embryology,  pathology*
Lumbosacral Region
Neural Tube Defects / diagnosis,  etiology*
Spinal Neoplasms / complications*,  embryology,  pathology*

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