Document Detail


Pathogenesis of listeriosis during pregnancy.
MedLine Citation:
PMID:  23347534     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Listeria monocytogenes causes several clinical manifestations in humans and domestic animals. This bacterium is a saprophyte in soil and ensiled feeds, which are sources of infection for food producing animals (i.e. ruminants). The most common route of infection for people is via ingestion of contaminated ready-to-eat food products such as produce, soft cheeses and deli meats. In the United States, L. monocytogenes causes relatively few cases of clinical disease compared to other food-borne pathogens. However, clinical listeriosis is associated with high mortality, especially in immunocompromised patients, pregnant women, neonates, and the elderly. Listeria is an intracellular pathogen, which has been widely used in basic research to elucidate mechanisms of molecular pathogenesis and protective cell-mediated immunity. Despite the sizeable knowledge on L. monocytogenes pathogenesis, key points regarding listeriosis during pregnancy and the perinatal period remain unknown. This review summarizes listeriosis in humans and domestic animals during pregnancy, and animal models used to study the pathogenesis and immune response to L. monocytogenes infection during these periods.
Authors:
Keith P Poulsen; Charles J Czuprynski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-25
Journal Detail:
Title:  Animal health research reviews / Conference of Research Workers in Animal Diseases     Volume:  -     ISSN:  1475-2654     ISO Abbreviation:  Anim Health Res Rev     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083072     Medline TA:  Anim Health Res Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-10     Citation Subset:  -    
Affiliation:
Department of Clinical Sciences, Oregon State University, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
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