| Pathogenesis of involutional ectropion and entropion: the involvement of matrix metalloproteinases in elastic fiber degradation. | |
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MedLine Citation:
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PMID: 21574802 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To determine the elastic fiber content and ultrastructure as well as the expression of elastin-degrading enzymes in biopsy specimens from patients with involutional ectropion and entropion. Materials and Methods: Twenty consecutive patients with involutional ectropion (group 1) and twenty consecutive patients with entropion (group 2) were matched with twenty control patients (basal cell carcinoma) regarding age and gender. Full-thickness eyelid resections performed in study and control patients were examined by light and transmission electron microscopy, computer-assisted measurements, and immunohistochemistry using antibodies against matrix metalloproteinase (MMP)-2, MMP- 7, and MMP-9. The Kruskal-Wallis test and the Pearson chi-square test were performed. Results: Histopathologic analysis of the surgical specimens from patients with involutional ectropion and entropion showed a significant loss of elastic fibers in the eyelid skin, the pretarsal orbicularis oculi muscle, the perimeibomian tarsal stroma, and the intermeibomian tarsal stroma (P < 0.001). Residual elastic fibers revealed an abnormal ultrastructure. Immunohistochemistry demonstrated a significant overexpression of MMP- 2, MMP-7, and MMP-9 in the eyelid skin, the pretarsal orbicularis oculi muscle, the perimeibomian tarsal stroma, the intermeibomian tarsal stroma, and the conjunctiva in groups 1 and 2 compared to controls (P < 0.001). Conclusions: The present findings indicate that upregulation of elastolytic enzymes contributes to elastic fibre degradation in patients with involutional ectropion and entropion. |
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Authors:
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Renato W Damasceno; Ludwig M Heindl; Carmen Hofmann-Rummelt; Rubens Belfort; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Leonard M Holbach |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Orbit (Amsterdam, Netherlands) Volume: 30 ISSN: 1744-5108 ISO Abbreviation: Orbit Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8301221 Medline TA: Orbit Country: England |
Other Details:
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Languages: eng Pagination: 132-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Eye Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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