Document Detail


Pathogenesis of hypertension in spontaneously hypertensive rats: definite evidence against a pressor role of vasopressin.
MedLine Citation:
PMID:  6697549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A number of experiments were performed in order to investigate the possible importance of vasopressin (AVP) in the pathogenesis of high blood pressure in spontaneously hypertensive rats of the stroke prone strain (SHRSP). Radioimmunological studies revealed reduced concentrations of AVP in the plasma and brain of SHRSP as compared to normotensive controls. Intravenous administration of an AVP pressor antagonist had no significant influence on mean arterial blood pressure, cardiac output and total peripheral resistance in SHRSP. Crossbreeding of SHRSP with rats homozygous for hypothalamic diabetes insipidus resulted in the development of a new strain of rats which show high blood pressure despite of a complete lack in AVP. These results argue strongly against a pressor role of AVP in the development or maintenance of hypertension in SHRSP.
Authors:
R E Lang; D Ganten; U Ganten; W Rascher; T Unger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  6     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1984  
Date Detail:
Created Date:  1984-04-17     Completed Date:  1984-04-17     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine Vasopressin / analysis,  antagonists & inhibitors
Blood Pressure
Brain Chemistry
Hypertension / etiology*
Male
Oxytocin / analysis
Rats
Rats, Inbred Strains
Vasopressins / biosynthesis,  physiology*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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