Document Detail

Pathogenesis of human cholesterol cholelithiasis.
MedLine Citation:
PMID:  1089468     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of cholesterol cholelithiasis in humans has been studied by means of three techniques. The cholesterol-solubilizing capacity of bile may be determined by estimation of the relative composition of the three major lipid constituents of bile. Consistent reduction in the cholesterol-carrying capacity of gallbladder bile of persons with gallstones when compared with normal subjects has not been shown. Normal subjects frequently have supersaturated bile. Secretion rates of biliary lipids have been estimated by two methods; with the method that appears to be more physiologic no change in lipid secretion rates was found in gallstone patients. Bile acid pool size has been measured by isotope dilution techniques; it is reduced in patients with gallstones. It is not clear whether this reduction is important in the pathogenesis of cholesterol cholelithiasis, for the bile acid secretion rate is normal because of an increased rate of cycling of the pool through the enterohepatic circulation. The role of the gallbladder in the genesis of cholesterol cholelithiasis may be more important than has been realized.
S M Strasberg; M M Fisher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  112     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-10     Completed Date:  1975-05-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  484-8     Citation Subset:  AIM; IM    
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MeSH Terms
Bile / analysis
Bile Acids and Salts / analysis,  biosynthesis,  secretion
Cholelithiasis / etiology*,  metabolism
Cholesterol* / analysis
Gallbladder / physiopathology
Intestines / blood supply
Liver / secretion
Liver Circulation
Phosphatidylcholines / secretion
Phospholipids / analysis
Radioisotope Dilution Technique
Reg. No./Substance:
0/Bile Acids and Salts; 0/Phosphatidylcholines; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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