Document Detail

Pathogenesis and histopathology of saccular aneurysms: review of the literature.
MedLine Citation:
PMID:  1982169     Owner:  NLM     Status:  MEDLINE    
In this paper, the major theories on the formation and growth of saccular aneurysms are reviewed on the basis of previous clinical, pathological and experimental studies. Which is the critical layer is still the focus of debate. Current ideas can be summarized as follows: most researchers think that disruption of the internal elastic lamina is an essential requirement for the creation of saccular aneurysms because it is this layer that provides most of the strength to the arterial wall, especially in cerebral arteries. Degeneration of this layer is a constant feature of all saccular aneurysms. A coexisting medial defect and haemodynamic stress at an apex may aggravate degeneration at that point. Hypertension does not seem to be the major factor in some aneurysm patients, but it may facilitate the formation and growth of saccular aneurysms. An atheroma is often associated with saccular aneurysms, but its effect on this pathological process is still unknown. Other factors are discussed concisely. Previous experimental methods and their results pertaining to the formation and growth of this type of aneurysm are also reviewed. A reproducible animal model is still required to allow various theories to be tested.
G Yong-Zhong; H A van Alphen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurological research     Volume:  12     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-10     Completed Date:  1991-05-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Department of Neurosurgery, Free University Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Blood Pressure
Cerebral Arteries / pathology
Cerebrovascular Circulation
Disease Models, Animal
Intracranial Aneurysm / congenital,  etiology*,  pathology
Intracranial Arteriosclerosis / complications,  pathology
Stress, Mechanical

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