Document Detail

Pathogenesis of giant somatosensory evoked potentials in progressive myoclonic epilepsy.
MedLine Citation:
PMID:  3919884     Owner:  NLM     Status:  MEDLINE    
Fifty-seven consecutive patients with myoclonus from various causes were studied by electrophysiological techniques. Giant somatosensory evoked potentials (SEPs) were observed almost exclusively in patients with progressive myoclonic epilepsy (PME) and diseases with similar clinical features that included lipidosis, neuronal ceroid lipofuscinosis and posthypoxic myoclonus. On the basis of combinations of the giant SEP and the myoclonus-related cortical spike demonstrated by jerk-locked averaging, myoclonus in these patients was classified into four types. In patients with 'cortical reflex' myoclonus (type I) who showed both the giant SEP and the myoclonus-related cortical spike, these two cortical activities were similar in terms of wave form, scalp topography, time relationship to either the long latency (C) reflex or myoclonus, the following cortical excitability, the effect of antimyoclonus drugs and alterations during slow wave sleep. It is therefore postulated that the giant SEP is generated, at least in part, by common physiological mechanisms to the myoclonus-related cortical spike, or that the latter may comprise a constituent of the former. In most patients with PME or allied diseases, both afferent and efferent components of the SEP are enhanced, but in some patients, only one of the two components seems to be predominantly enhanced.
H Shibasaki; Y Yamashita; R Neshige; S Tobimatsu; R Fukui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  108 ( Pt 1)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-14     Completed Date:  1985-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-40     Citation Subset:  AIM; IM    
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MeSH Terms
Epilepsies, Myoclonic / physiopathology*
Evoked Potentials, Somatosensory*
Middle Aged

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