| Pathogenesis of gallstones. | |
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MedLine Citation:
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PMID: 20478481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesterol gallstone formation is a complex process and involves phase separation of cholesterol crystals from supersaturated bile. In most cases, cholesterol hypersecretion is considered the primary event in gallstone formation. The sterol is transported through the hepatocytic canalicular membrane by ABCG5-G8. Expression of this transport protein is regulated by transcription factor Liver X Receptor-alpha, which may be responsible for biliary hypersecretion. Hydrophobic bile salt pool, bile concentration, excess pronucleating mucin, and impaired gallbladder and intestinal motility are secondary phenomena in most cases but nevertheless may contribute to gallstone formation. |
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Authors:
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Niels Gerard Venneman; Karel Johannes van Erpecum |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Gastroenterology clinics of North America Volume: 39 ISSN: 1558-1942 ISO Abbreviation: Gastroenterol. Clin. North Am. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706257 Medline TA: Gastroenterol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 171-83, vii Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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biosynthesis Bile Acids and Salts / secretion* Biliary Dyskinesia / complications*, metabolism, physiopathology Biological Transport / physiology Cholesterol / secretion* Crystallization Disease Progression Gallbladder Emptying / physiology* Gallstones* / etiology, metabolism, physiopathology Humans Lipoproteins / biosynthesis Sterols / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/ABCG5 protein, human; 0/ABCG8 protein, human; 0/ATP-Binding Cassette Transporters; 0/Bile Acids and Salts; 0/Lipoproteins; 0/Sterols; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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