Document Detail

Pathogenesis of follicular lymphoma.
MedLine Citation:
PMID:  23023713     Owner:  NLM     Status:  MEDLINE    
The hallmark t(14;18)(q32;q21) in follicular lymphoma (FL) results in constitutive overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center apoptotic program. Most tumors are characterized by recurrent secondary genetic alterations including genomic gains, losses, and mutations, some providing a growth advantage, including alterations in MLL2, EPHA7, TNFRSF14, and EZH2. The sequence in which these events occur and how they contribute to progression and ultimately to transformation is unclear. Lastly, crosstalk between neoplastic B cells and non-neoplastic immune and stromal cells in the microenvironment plays an important role in sustaining tumor cell growth, cultivating immune privilege, and promoting transformation.
Robert Kridel; Laurie H Sehn; Randy D Gascoyne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3424-31     Citation Subset:  AIM; IM    
Center for Lymphoid Cancer, BC Cancer Agency, Department of Pathology and Laboratory Medicine, and Division of Medical Oncology, University of British Columbia, Vancouver, British Columbia, Canada.
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MeSH Terms
Antigen Presentation
B-Lymphocytes / pathology*
Cell Division
Cell Transformation, Neoplastic / genetics*
Chromosome Aberrations
Chromosomes, Human, Pair 14 / genetics*,  ultrastructure
Chromosomes, Human, Pair 18 / genetics*,  ultrastructure
Disease Progression
Genes, bcl-2
Lymphoma, Follicular / drug therapy,  etiology,  genetics*,  pathology
Macrophages / pathology
Models, Biological
Molecular Targeted Therapy
Neoplasm Proteins / biosynthesis,  genetics*,  physiology
Neoplastic Stem Cells / pathology
Proto-Oncogene Proteins c-bcl-2 / biosynthesis,  genetics*,  physiology
Stem Cell Niche
T-Lymphocytes / pathology
Translocation, Genetic*
Tumor Microenvironment / drug effects
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Neoplasm Proteins; 0/Proto-Oncogene Proteins c-bcl-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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