Document Detail

[Pathogenesis of endogenous endotoxemia in chronic liver disease--with special reference to the experimental fatty liver in germfree animals].
MedLine Citation:
PMID:  6328243     Owner:  NLM     Status:  MEDLINE    
The effect of intestinal bacterial flora and endotoxin on fatty liver with germfree (GF) and conventional (CV) rat in the 12th and 24th week was investigated after giving fatty diet which was added 1% cholesterol-0.5% cholic acid to the basic diet. Results are as follows. Serum biochemistry Serum GOT, GPT, ALP and cholesterol values increased after giving the fatty diet in both groups. Limulus Gelation Test In CV group, endotoxin was detected in 2 of 10 cases in portal blood and was completely absent in arterial blood. After the fatty diet, endotoxin increased gradually both in portal and arterial blood. Cyclic AMP values on glucagon challenge (P/B ratio) In both groups, the levels of the P/B ratio maintained low values compared with control. In CV group, the values were lower in endotoxin positive cases than negative ones. Hepatic carbohydrate metabolism Abnormal hepatic F6P , glucose, FDP and PEP values were observed in CV group and reduction of the levels of hepatic F6P , G6P and glucose values were remarkable in GF group. Hepatic G6P in CV group and FDP in GF group remained unchanged. Impairment of F6P and G6P in CV group, was significant in endotoxin positive cases than in negative ones.
H Tamura
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Nihon Geka Gakkai zasshi     Volume:  84     ISSN:  0301-4894     ISO Abbreviation:  Nihon Geka Gakkai Zasshi     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1984-07-20     Completed Date:  1984-07-20     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  0405405     Medline TA:  Nihon Geka Gakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  602-11     Citation Subset:  IM    
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MeSH Terms
Carbohydrate Metabolism
Cyclic AMP / blood
Endotoxins / blood*
Fatty Liver / metabolism*,  pathology
Germ-Free Life
Liver / metabolism,  pathology
Organ Size
Reg. No./Substance:
0/Endotoxins; 60-92-4/Cyclic AMP

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