Document Detail

Pathogenesis of early atherosclerotic lesions in infants.
MedLine Citation:
PMID:  15239349     Owner:  NLM     Status:  MEDLINE    
High serologic lipid levels, infections, and genetic susceptibility have been proposed as possible etiologic factors of initial atherosclerotic lesions of the coronary arteries in infancy. At a recent WHO annual meeting, it was stated that breast milk substitutes cause irreparable damage in infants. This prompted us to verify whether formula feeding and parental cigarette smoking might play a role in the pathogenesis of early atherosclerotic alterations in infancy. The major epicardial coronary arteries from 36 infants dying suddenly and unexpectedly (sudden infant death syndrome) were embedded in paraffin and serially cut for histologic examination. In 67% of the cases, multifocal coronary early atherosclerotic lesions of varying entities were detected. The alterations ranged from focal plaques with mild myointimal thickening to juvenile soft plaques reducing the arterial lumen. A significant correlation was observed between the early atherosclerotic lesions and the risk factors considered. In particular, we noted different morphologic patterns related to formula feeding and cigarette smoking. Baby formula feeding and parental cigarette smoking might have an atherogenic effect on the coronary walls as from the first months of life. The lesions appear to be larger and more diffuse when both these atherogenic factors are present.
Luigi Matturri; Giulia Ottaviani; Giancarlo Corti; Anna M Lavezzi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology, research and practice     Volume:  200     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  403-10     Citation Subset:  IM    
Institute of Pathology, University of Milan, Via della Commenda 19, 20122 Milan, Italy.
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MeSH Terms
Arteriosclerosis / complications,  etiology*,  pathology*
Breast Feeding
Coronary Vessels / pathology*
Infant Formula*
Infant, Newborn
Myocytes, Smooth Muscle / pathology
Risk Factors
Sudden Infant Death / pathology
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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