Document Detail

Pathogenesis of diabetic neuropathy: the role of the n-6 essential fatty acids and their eicosanoid derivatives.
MedLine Citation:
PMID:  2146062     Owner:  NLM     Status:  MEDLINE    
A substantial disturbance of the metabolism of the n-6 essential fatty acids exists in both human and experimental diabetes mellitus. Disturbances of the essential fatty acids and of the 1- and 2-series prostaglandins derived from them create a variety of microvascular, haemorheological, and other abnormalities leading to reduced blood flow and neural hypoxia which will in turn produce a cycle of hypoxia. Disturbance of the n-6 pathway may also result in functional and structural abnormalities of the axon, the myelin, and membrane-bound proteins such as enzymes and receptors. Metabolic disturbances identified previously may have a synergistic effect in enhancing these pathogenetic changes.
G A Jamal
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  7     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-05     Completed Date:  1990-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  574-9     Citation Subset:  IM    
Department of Neurology, University of Glasgow, UK.
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MeSH Terms
Diabetes Complications
Diabetes Mellitus / metabolism
Diabetic Neuropathies / etiology*,  metabolism
Eicosanoids / metabolism*
Fatty Acids, Essential / metabolism,  physiology*
Reg. No./Substance:
0/Eicosanoids; 0/Fatty Acids, Essential

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