Document Detail

Pathogenesis of acute lung injury in rats with severe acute pancreatitis.
MedLine Citation:
PMID:  16286275     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute lung injury (ALI) is the most common and severe complication of severe acute pancreatitis (SAP). The elucidation of the mechanism of ALI contributes to the diagnosis and treatment of the illness. In this study, we studied the pathogenesis of ALI in rats with severe acute pancreatitis. METHODS: The rats were sacrificed at 1, 3, 5, 6, 9 and 12 hours after the establishment of the model of SAP. Pancreas and lung tissues were obtained for pathological study, and examination of microvascular permeability and myeloperoxidase (MPO) examination. The gene expressions of tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas and lung tissues were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: After the establishment of the SAP model, the degree of pancreatic and lung injury increased gradually along with the gradual increase of MPO activity and microvascular permeability. Gene expressions of TNF-alpha and ICAM-1 in the pancreas rose at 1 hour and peaked at 7 hours. In contrast, their gene expression in the lungs rose slightly at 1 hour and peaked at 9-12 hours. CONCLUSION: An obvious time window existed between SAP and lung injury, which is beneficial to the early prevention of the development of ALI.
Xue-Min Liu; Jun Xu; Zi-Fa Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  4     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  614-7     Citation Subset:  IM    
Department of Hepatobiliary Surgery, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
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MeSH Terms
Acute Disease
Disease Models, Animal
Intercellular Adhesion Molecule-1 / genetics
Lung / pathology*
Pancreas / pathology
Pancreatitis / pathology*
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha / genetics
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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